By LiveScience Staff

A slow starvation of the brain over time is one of the major triggers of the biochemistry that causes some forms of Alzheimer’s, according to a new study that is helping to crack the mystery of the disease’s origins.

An estimated 10 million baby boomers will develop Alzheimer’s in their lifetime, according to the Alzheimer’s Association. The disease usually begins after age 60, and risk rises with age. The direct and indirect cost of Alzheimer’s and other dementias is about $148 billion a year.

Robert Vassar of Northwestern University, the study’s lead author, found that when the brain doesn’t get enough of the simple sugar called glucose — as might occur when cardiovascular disease restricts blood flow in arteries to the brain — a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer’s.

Working with human and mice brains, Vassar discovered that a key brain protein is altered when the brain’s supply of energy drops. The altered protein, called eIF2alpha, increases the production of an enzyme that, in turn, flips a switch to produce the sticky protein clumps.

“This finding is significant because it suggests that improving blood flow to the brain might be an effective therapeutic approach to prevent or treat Alzheimer’s,” Vassar said.

The best ways to improve blood flow to the brain and thereby reduce the chances of getting Alzheimer’s is to reduce cholesterol intake, manage high blood pressure and exercise, especially entering mid-life.

“If people start early enough, maybe they can dodge the bullet,” Vassar said. For people who already have symptoms, vasodilators, which increase blood flow, may help the delivery of oxygen and glucose to the brain, he added. The study is published in the Dec. 26 issue of the journal Neuron.

No candy bars

When it comes to prevention of Alzheimer’s, eating candy bars is not the solution to improving the flow of blood glucose to the brain, Vassar told LiveScience.

A decreasing blood flow to the brain happens over time, as we age, and that slowly starves the brain of glucose. This could be a general aging phenomenon, or it could be that some individuals are particularly prone to it, Vassar said. Also, decreased blood flow is associated with atherosclerosis, or hardening of the arteries, and hypertension, or high blood pressure.

“We need to improve our cardiovascular health, not eat more sugar,” Vassar said. “What is coming out in terms of the epidemiological studies is that exercise during mid-life is one of the best prevention strategies for Alzheimer’s disease, so people should stay active physically, and they should watch their diets and reduce cholesterol intake, because cholesterol contributes to atherosclerosis, and that is true for the heart and the rest of the body as well as for the brain.”

Vassar said it also is possible that drugs could be designed to block the elF2alpha protein that begins the formation of the protein clumps, known as amyloid plaques.

Earlier Alzheimer’s findings

Ten years ago, Vassar discovered the enzyme, BACE1, that was responsible for making the sticky, fiber-like clumps of protein that form outside neurons and disrupt their ability to send messages.

But the cause of the high levels of the protein in people with the disease has been unknown. Vassar’s new study now shows that energy deprivation in the brain might be the trigger starting the process that forms plaques in Alzheimer’s.

Vassar said his work suggests that Alzheimer’s disease may result from a less severe type of energy deprivation than occurs in a stroke. Rather than dying, the brain cells react by increasing BACE1, which may be a protective response in the short term, but harmful in the long term.

“A stroke is a blockage that prevents blood flow and produces cell death in an acute, dramatic event,” Vassar said. “What we are talking about here is a slow, insidious process over many years where people have a low level of cardiovascular disease or atherosclerosis in the brain. It’s so mild, they don’t even notice it, but it has an effect over time because it’s producing a chronic reduction in the blood flow.”

Vassar said when people reach a certain age, some may get increased levels of the enzymes that cause a build-up of the plaques. “Then they start falling off the cliff,” he said.

Contrary to popular belief, recent studies have found that there are probably ways to regenerate brain matter.

Animal studies conducted at the National Institute on Aging Gerontology Research Center and the Johns Hopkins University School of Medicine, for example, have shown that both calorie restriction and intermittent fasting along with vitamin and mineral intake, increase resistance to disease, extend lifespan, and stimulate production of neurons from stem cells.

In addition, fasting has been shown to enhance synaptic elasticity, possibly increasing the ability for successful re-wiring following brain injury. These benefits appear to result from a cellular stress response, similar in concept to the greater muscular regeneration that results from the stress of regular exercise.

Additional research suggests that increasing time intervals between meals might be a better choice than chronic calorie restriction, because the resultant decline in sex hormones may adversely affect both sexual and brain performance. Sex steroid hormones testosterone and estrogen are positively impacted by an abundant food supply. In other words, you might get smarter that way, but it might adversely affect your fun in the bedroom, among other drawbacks.

But if your not keen on starving yourself, there are other options. Another recent finding, stemming from the Burnham Institute for Medical Research and Iwate University in Japan, reports that the herb rosemary contains an ingredient that fights off free radical damage in the brain. The active ingredient, known as carnosic acid (CA), can protect the brain from stroke and neurodegeneration such as Alzheimer’s and from the effects of normal aging.

Although researchers are patenting more potent forms of isolated compounds in this herb, unlike most new drugs, simply using the rosemary in its natural state may be the most safe and clinically tolerated because it is known to get into the brain and has been consumed by people for over a thousand years. The herb was used in European folk medicine to help the nervous system.

Another brain booster that Bruce N. Ames, Ph.D., a professor of biochemistry and molecular biology at the University of California, Berkeley, swears by his daily 800 mg of alpha-lipoic acid and 2,000 mg of acetyl-L-carnitine, chemicals which boost the energy output of mitochondria that power our cells. Mitochondrial decay is a major factor in aging and diseases such as Alzheimer’s and diabetes. Elderly rats on these supplements had more energy and ran mazes better.

Omega-3s fatty acids DHA and EPA found in walnuts and fatty fish (such as salmon, sardines, and lake trout) are thought to help ward off Alzheimer’s disease. (In addition, they likely help prevent depression and have been shown to help prevent sudden death from heart attack).

Turmeric, typically found in curry, contains curcumin, a chemical with potent antioxidant and anti-inflammatory properties. In India, it is even used as a salve to help heal wounds. East Asians also eat it, which might explain their lower rates (compared to the United States) of Parkinson’s disease and Alzheimer’s disease, in addition to various cancers. If curry isn’t part of your favorite cuisines, you might try a daily curcumin supplement of 500 to 1,000 mg.

Physical exercise may also have beneficial effects on neuron regeneration by stimulating regeneration of brain and muscle cells via activation of stress proteins and the production of growth factors. But again, additional research suggests that not all exercise is equal. Interestingly, some researchers found that exercise considered drudgery was not beneficial in neuronal regeneration, but physical activity that was engaged in purely for fun, even if equal time was spent and equal calories were burned, resulted in neuronal regeneration.

Exercise can also help reduce stress, but any stress-reducing activity, such as meditation and lifestyle changes, can help the brain. There is some evidence that chronic stress shrinks the parts of the brain involved in learning, memory, and mood. (It also delays wound healing, promotes atherosclerosis, and increases blood pressure.)

It should go without saying that short-term cognitive and physical performance is not boosted by fasting, due to metabolic changes including decrease in body temperature, decreased heart rate and blood pressure and decreased glucose and insulin levels, so you’re better off not planning a marathon or a demanding work session during a fasting period.

As part of a healthy lifestyle the prescription of moderating food intake, exercising, and eating anti-oxidant rich foods is what we’ve long known will boost longevity, but it’s good to know that we can bring our brains along with us as we make it into those golden years without being the 1 in 7 who suffers from dementia. Keep your fingers crossed and eat some rosemary chicken.

– The Daily Galaxy

By Gentil Garçon (flickr)

Ethiopia, what a strange country! Fields seem in capacity to feed the people of Ethiopia, but at the same time we are faced with one of the worst famine in 20 years. The regime of Ethiopia (Meles Zenawi firstly) is one of the most useless in the world. [Mr. Garcon, corn and other crops grown in Ethiopia are being exported by companies affiliated with the ruling party while millions of Ethiopians are starving. That’s why we have been saying that the Meles regime is a vampire that is sucking the life blood of Ethiopia.]

ADDIS ABABA, Ethiopia (Garowe Online) – At least 1,700 Somalis have been rounded up in the Ethiopian capital of Addis Ababa over the past 48 hours, Radio Garowe reports.

Sources in Addis Ababa said all the detainees were Somali men, some of whom were pulled out of their homes for questioning by Woyanne security agents.

“The Somali men who were arrested were here [in Addis Ababa] for different reasons, but mainly as transit” to other parts of the world, said Addis Ababa resident Mulki Mohamed.

She indicated that the men are being held at seven different locations, adding: “We do not know the real reason for the arrests.”

Addis Ababa has expressed increasing concern of terror attacks inside Ethiopian cities, with emerging reports indicating that the Somali detainees were asked questions about any links to Somali insurgent groups.

KUALA LUMPUR (Xinhua) — A German warship on Thursday foiled an attempt by pirates to seize an Egyptian bulk carrier off the troubled Somali coast, the Kuala Lumpur-based International Maritime Bureau (IMB) has said.

One of the crew was injured by gunshots during the attack as the carrier was passing through the Gulf of Aden toward Asia, said Noel Choong, chief of the reporting center of the anti-piracy IMB.

“The pirates were randomly firing at the ship, resulting in one of the crew members sustaining injuries to his leg,” he said.

The German navy frigate Karlsruhe dispatched a helicopter to the scene after receiving an alert from a passing ship and the pirates fled as the chopper arrived, according to a statement from the German military.

The injured crewman received medical treatment on the Karlsruhe, the statement said.

Choong warned that pirate attacks are still mounting despite recent international efforts to secure the Somali coast, one of the busiest marine channels in the world.

“Despite increased naval patrols, pirates are continuing to attack ships because the warships cannot be everywhere at the same time. But we are pleased with the quick assistance by the coalition force,” Choong said.

More than a dozen warships from countries including Britain, the United States, France, Germany, Iran and India are now patrolling the gulf. Two Chinese destroyers and a support vessel were to depart Friday from Sanya in southern China to join the international fleet of warships.

According to the IMB, more than 120 attacks have occurred in Somali waters this year and more than 240 crew members are still being held hostage by pirates.